01 · 1960s
Desmopressin
Czechoslovakia / Europe
A vasopressin analog used for specific bleeding and water-balance disorders.
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Peptide medicines with established, indication-specific clinical use
02 · 1923 discovery
Glucagon
United States
An endogenous peptide and emergency medicine for severe hypoglycemia.
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03 · 1970s
Leuprolide
United States / Japan
A GnRH analog used in indication-specific hormonal treatment.
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04 · 1979
Octreotide
Switzerland
A somatostatin analog used for acromegaly and several neuroendocrine indications.
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05 · 1995; approved 2010
Tesamorelin
Montreal, Canada
Approved for excess abdominal fat in adults with HIV and lipodystrophy.
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06 · approved 2019
Bremelanotide
United States
Approved for narrowly defined acquired, generalized HSDD in certain premenopausal women.
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