THE 60-SECOND GUIDE
Glucagon
Approved human use · product-specific labels.
Guide prepared November 13, 2026 · profile review dates retained
What is it?
Glucagon signals the liver to release glucose and helps defend against falling blood sugar. Approved glucagon medicines can be used for severe hypoglycemia. The hormone is part of normal glucose regulation; the rescue medicine is a specific product with its own instructions and limitations. [1]
Potential benefits
Raises blood glucose through liver signaling. Approved products can treat severe hypoglycemia. [1]
Evidence & its limits
Glucagon rescue depends on stored glucose in the liver. The prescribing information warns that it may be ineffective when liver glycogen is depleted, including in starvation or chronic hypoglycemia. A rescue product therefore does not eliminate the need for an emergency care plan. [1]
Risks & unknowns
Nausea and vomiting can occur. Emergency effectiveness can depend on adequate liver glycogen and correct use. [1]
Status & scope
Approved glucagon medicines can be used for severe hypoglycemia. [1]
The question to ask
Does the evidence match the exact product, route, condition and outcome being discussed? Check the full record and its review dates. This summary is selective; the product label and clinical assessment contain additional warnings and contraindications.
CHECK THE RECORD
Sources & review
- Full evidence record, references and review dates
- FDA Drugs@FDA database
- MedlinePlus: medication-specific uses and precautions
- DailyMed: glucagon for injection prescribing information
Guide prepared November 13, 2026 · profile review dates retained. Condensed from the linked site evidence record. This format update is not a new clinical review of every source. Consult the full profile for its evidence-review dates and targeted updates.
Selective educational summary, not treatment or dosing advice. Existing profile review dates retained; no independent clinical review.